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S100A9-Dependent CXCR2 <sup>hi</sup> Neutrophils Mediate Systemic Immune Suppression and Checkpoint Resistance in Metastatic TNBC

2026-06-12

Abstract excerpt

Most high-dimensional studies of tumor-immune interactions focus on metastatic models, limiting insight into how immune remodeling in primary tumors shapes metastatic competence. Here, integrating single-cell RNA sequencing, CyTOF, and functional studies across metastatic (4T1) and non-invasive (EMT6) triple-negative breast cancer (TNBC) murine models, we define tumor state-specific immune programs that distinguis...

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Literature Corpus work
2db1f103-71fb-5fc7-bff9-efbc926fc906
DOI
10.64898/2026.06.09.731132
Open publication

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S100A9-Dependent CXCR2 <sup>hi</sup> Neutrophils Mediate Systemic Immune Suppression and Checkpoint Resistance in Metastatic TNBCDOI 10.64898/2026.06.09.731132
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