Article

Spatial Gene Expression Analysis Reveals Drivers of Extremely Early Lymph Node Metastasis in Breast Cancer

2025-09-23

Abstract excerpt

<title>Abstract</title> <p>Lymph node metastasis critically influences breast cancer prognosis; however, the cellular mechanisms underlying the earliest metastatic events remain unclear. In spatial transcriptomic analysis of a patient with breast cancer at single cell resolution, we identified 30 tumor cells representing the initial metastatic seeding in a lymph node. These cells originated from multiple epitheli...

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Literature Corpus work: c97a46ef-b537-5d8a-9d49-3b38114fa725
DOI: 10.21203/rs.3.rs-7371816/v1

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