Article

Spatial Transcriptomics of TNBC tumours and corresponding lymph node metastasis reveals immune hubs driven by TNF/NF-κB signalling of TMSB4X and CD74 expressing cells

2026-03-17

Abstract excerpt

<h4>Purpose</h4> Lymph node metastasis is a critical prognostic factor in triple-negative breast cancer (TNBC), but the spatial organization of signalling networks driving metastatic colonization and persistence remains poorly defined. Understanding these networks may reveal therapeutic vulnerabilities in metastatic TNBC. <h4>Methods</h4> We applied Visium spatial transcriptomics to paired primary tumours and ly...

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Literature Corpus work: d90e101a-dee7-537b-b1c4-aea01b545e15
DOI: 10.64898/2026.03.15.711865

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