Article

Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74 <sup>+</sup> lipid-associated macrophage niche driving polymetastatic breast cancer

2026-02-03

Abstract excerpt

Systemic, multi-organ metastasis is the primary cause of breast cancer mortality, yet the biological mechanisms that allow disseminated tumor cells to simultaneously colonize physiologically diverse tissues remain poorly understood. Current paradigms focus on organ-specific tropism, largely overlooking the potential for systemic, conserved and synchronized programs that facilitate widespread colonization. Here, we...

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Literature Corpus work: ca22cbdb-01de-5da9-b6b7-df6679246ad4
DOI: 10.64898/2026.01.31.701004

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Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74 <sup>+</sup> lipid-associated macrophage niche driving polymetastatic breast cancerDOI 10.64898/2026.01.31.701004Read

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