Article

ATFS-1 regulates peroxisome assembly genes and protects both mitochondria and peroxisomes during peroxin perturbations

2022-09-10

Abstract excerpt

Peroxisome biogenesis disorders lead to a myriad of clinical manifestations, among which is the dysfunction of the mitochondria. Mitochondria dysfunction is typically sensed by the UPR mt , a broad protective transcriptional response governed by the transcription factor ATFS-1. Here, we investigated the role of the UPR mt during peroxisomal stress. We show that mutations or knockdown of peroxins, the genes requi...

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Literature Corpus work: f4ba190f-f9a7-5a3d-bab4-19bd81ab95d7
DOI: 10.1101/2022.09.09.507280

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