Article

Prediction of the structural interface between fibroblast growth factor23 and Burosumab using alanine scanning and molecular docking

2022-05-16

Abstract excerpt

Burosumab, an FGF23 targeting monoclonal antibody, was approved by the FDA in 2018 for use in children and adults with X-linked hypophosphatemia (or XLH). While several clinical studies have demonstrated the long-term safety and efficacy of Burosumab, the molecular basis of FGF23-Burosumab interaction which underpins its mechanism of action remains unknown. In this study, we first employed molecular docking combin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f4acb601-9412-5487-8bbe-fd3af2072f21
DOI: 10.21203/rs.3.rs-1630525/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Prediction of the structural interface between fibroblast growth factor23 and Burosumab using alanine scanning and molecular dockingDOI 10.21203/rs.3.rs-1630525/v1Read

Structural Basis of Antibody Conformation and Stability Modulation by Framework Somatic HypermutationSemantic proximity Read

Epitope mapping via in vitro deep mutational scanning methods and its applicationsSemantic proximity Read

Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfacesSemantic proximity Read

AbAgym: a well-curated dataset for the mutational analysis of antibody-antigen complexes.Semantic proximity Read

Regulatory approved monoclonal antibodies contain framework mutations predicted from human antibody repertoiresSemantic proximity Read

Computational Stabilization of the Human VH Germline Repertoire to Enable Conditional Multi-Specific Therapeutic DevelopmentSemantic proximity Read

Regulatory Approved Monoclonal Antibodies Contain Framework Mutations Predicted From Human Antibody Repertoires.Semantic proximity Read

Deep mutational scanning reveals transmembrane features governing surface expression of the B cell antigen receptor.Semantic proximity Read

Preventing pathogenic dimerization in a misfolded antibody light chain through the design of an inhibitory peptideSemantic proximity Read

Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swappingSemantic proximity Read

Deciphering cross-species reactivity of LAMP-1 antibodies using deep mutational epitope mapping and AlphaFold.Semantic proximity Read

Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM.Semantic proximity Read