Article

Preventing pathogenic dimerization in a misfolded antibody light chain through the design of an inhibitory peptide

2025-09-20

Abstract excerpt

Immunoglobulin light chain (AL) amyloidosis is the most common form of systemic amyloidosis. The disease correlates with the formation of insoluble aggregates mostly composed by patient-specific antibody light chains, whose hypervariable regions make each case unique and highlight the need for personalized therapeutics. In this study, we focused on a pathogenic homodimer we previously obtained from a patient-deriv...

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Literature Corpus work: 0d810514-c049-58ce-9653-9fe2597a7af0
DOI: 10.1101/2025.09.16.676588

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