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Article

Deep mutational scanning reveals transmembrane features governing surface expression of the B cell antigen receptor.

Frontiers in immunology - 1 Jan 2024

Ramesh Samyuktha, Go Margareta, Call Matthew E, Call Melissa J

Abstract excerpt

B cells surveil the body for foreign matter using their surface-expressed B cell antigen receptor (BCR), a tetrameric complex comprising a membrane-tethered antibody (mIg) that binds antigens and a signaling dimer (CD79AB) that conveys this interaction to the B cell. Recent cryogenic electron microscopy (cryo-EM) structures of IgM and IgG isotype BCRs provide the first complete views of their architecture,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, B-Cell

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Identifiers

PMID: 39108267
DOI: 10.3389/fimmu.2024.1426795
PMCID: PMC11300204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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