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Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping

27 Jan 2017

Abstract excerpt

Abstract Therapeutic and diagnostic applications of monoclonal antibodies often require careful selection of binders that recognize specific epitopes on the target molecule to exert a desired modulation of biological function. Here we present a proof-of-concept application for the rational design of an epitope-specific antibody binding with the target protein Keap1, by grafting pre-defined structural interaction...

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PMID: 28128368
DOI: 10.1038/srep41306

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