Article

Regulatory approved monoclonal antibodies contain framework mutations predicted from human antibody repertoires

2021-06-22

Abstract excerpt

Monoclonal antibodies (mAbs) are an important class of therapeutics used to treat cancer, inflammation, and infectious diseases. Identifying highly developable mAb sequences in silico could greatly reduce the time and cost required for therapeutic mAb development. Here, we present position-specific scoring matrices (PSSMs) for antibody framework mutations developed using natural human antibody repertoire sequence...

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Literature Corpus work: b874321b-01dc-5872-ad41-7c7ded5506e7
DOI: 10.1101/2021.06.22.449488

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