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Article

Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM.

Biochimica et biophysica acta - 1 Oct 2015

Chromikova Veronika, Mader Alexander, Hofbauer Stefan, Göbl Christoph, Madl Tobias, Gach Johannes S, Bauernfried Stefan, Furtmüller Paul G, Forthal Donald N, Mach Lukas, Obinger Christian, Kunert Renate

Abstract excerpt

Immunoglobulins M (IgMs) are gaining increasing attention as biopharmaceuticals since their multivalent mode of binding can give rise to high avidity. Furthermore, IgMs are potent activators of the complement system. However, they are frequently difficult to express recombinantly and can suffer from low conformational stability. Here, the broadly neutralizing anti-HIV-1 antibody 2G12 was class-switched to IgM and...

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Identifiers

PMID: 25748881
DOI: 10.1016/j.bbapap.2015.02.018
PMCID: PMC4582045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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