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Regulatory Approved Monoclonal Antibodies Contain Framework Mutations Predicted From Human Antibody Repertoires.

Frontiers in immunology - 1 Jan 2021

Petersen Brian M, Ulmer Sophia A, Rhodes Emily R, Gutierrez-Gonzalez Matias F, Dekosky Brandon J, Sprenger Kayla G, Whitehead Timothy A

Abstract excerpt

Monoclonal antibodies (mAbs) are an important class of therapeutics used to treat cancer, inflammation, and infectious diseases. Identifying highly developable mAb sequences in silico could greatly reduce the time and cost required for therapeutic mAb development. Here, we present position-specific scoring matrices (PSSMs) for antibody framework mutations developed using baseline human antibody repertoire...

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Identifiers

PMID: 34646268
DOI: 10.3389/fimmu.2021.728694
PMCID: PMC8503325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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