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Article

Deciphering cross-species reactivity of LAMP-1 antibodies using deep mutational epitope mapping and AlphaFold.

mAbs - 1 Jan 2000

Pruvost Tiphanie, Mathieu Magali, Dubois Steven, Maillère Bernard, Vigne Emmanuelle, Nozach Hervé

Abstract excerpt

Delineating the precise regions on an antigen that are targeted by antibodies has become a key step for the development of antibody therapeutics. X-ray crystallography and cryogenic electron microscopy are considered the gold standard for providing precise information about these binding sites at atomic resolution. However, they are labor-intensive and a successful outcome is not guaranteed. We used deep...

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Identifiers

PMID: 36797224
DOI: 10.1080/19420862.2023.2175311
PMCID: PMC9980635

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