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High-grade serous ovarian carcinoma organoids as models of chromosomal instability

2022-09-02

Abstract excerpt

High-grade serous ovarian carcinoma (HGSOC) is the most genomically complex cancer, characterised by ubiquitous TP53 mutation, profound chromosomal instability and heterogeneity. The mutational processes driving chromosomal instability in HGSOC can be distinguished by specific copy number signatures. To develop clinically relevant models of these mutational processes we derived 15 continuous HGSOC patient-derived...

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Literature Corpus work
f4579dd3-babc-5a25-9899-3ee4e8fbe03b
DOI
10.1101/2022.09.01.506155
Open publication

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High-grade serous ovarian carcinoma organoids as models of chromosomal instabilityDOI 10.1101/2022.09.01.506155
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