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A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids

5 May 2023

Abstract excerpt

The broad research use of organoids from high-grade serous ovarian cancer (HGSC) has been hampered by low culture success rates and limited availability of fresh tumor material. Here, we describe a method for generation and long-term expansion of HGSC organoids with efficacy markedly improved over previous reports (53% vs. 23%-38%). We established organoids from cryopreserved material, demonstrating the...

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PMID: 37148882
DOI: 10.1016/j.devcel.2023.04.012

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