Article
Exploiting a living biobank to delineate mechanisms underlying disease-specific chromosome instability
17 Aug 2023
Abstract excerpt
Chromosome instability (CIN) is a cancer hallmark that drives tumour heterogeneity, phenotypic adaptation, drug resistance and poor prognosis. High-grade serous ovarian cancer (HGSOC), one of the most chromosomally unstable tumour types, has a 5-year survival rate of only ~30% - largely due to late diagnosis and rapid development of drug resistance, e.g., via CIN-driven ABCB1 translocations. However, CIN is also...
Topics
Join the communities discussing this publication.