Article
A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity.
Nature communications - 13 Feb 2020
Nelson Louisa, Tighe Anthony, Golder Anya, Littler Samantha, Bakker Bjorn, Moralli Daniela, Murtuza Baker Syed, Donaldson Ian J, Spierings Diana C J, Wardenaar René, Neale Bethanie, Burghel George J, Winter-Roach Brett, Edmondson Richard, Clamp Andrew R, Jayson Gordon C, Desai Sudha, Green Catherine M, Hayes Andy, Foijer Floris, Morgan Robert D, Taylor Stephen S
Abstract excerpt
High-grade serous ovarian carcinoma is characterised by TP53 mutation and extensive chromosome instability (CIN). Because our understanding of CIN mechanisms is based largely on analysing established cell lines, we developed a workflow for generating ex vivo cultures from patient biopsies to provide models that support interrogation of CIN mechanisms in cells not extensively cultured in vitro. Here, we describe a...
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