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Article

High-grade serous ovarian carcinoma organoids as models of chromosomal instability.

eLife - 11 May 2023

Vias Maria, Morrill Gavarró Lena, Sauer Carolin M, Sanders Deborah A, Piskorz Anna M, Couturier Dominique-Laurent, Ballereau Stéphane, Hernando Bárbara, Schneider Michael P, Hall James, Correia-Martins Filipe, Markowetz Florian, Macintyre Geoff, Brenton James D

Abstract excerpt

High-grade serous ovarian carcinoma (HGSOC) is the most genomically complex cancer, characterized by ubiquitous TP53 mutation, profound chromosomal instability, and heterogeneity. The mutational processes driving chromosomal instability in HGSOC can be distinguished by specific copy number signatures. To develop clinically relevant models of these mutational processes we derived 15 continuous HGSOC...

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BRCA gene mutations in cancer
Chromosomal Instability
Genomics
Mutation
Organoids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian cancer diagnosis and treatment

Ovarian Neoplasms

Reproductive Biology and Fertility

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Identifiers

PMID: 37166279
DOI: 10.7554/eLife.83867
PMCID: PMC10174694

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