Article

Long-read, whole-genome sequencing and chemotherapy response of two patient-derived organoids from a TP53- and KRAS-mutant ovarian carcinoma

2026-07-10

Abstract excerpt

Patient-derived organoids (PDOs) have transformed translational cancer research, allowing tractable models that better represent clinical features than traditional immortalized cell lines. Here we describe two PDOs with differential responses to carboplatin derived from sequential ascites fluid collections from a patient with high-grade müllerian carcinoma, that could not be further subclassified on the omental bi...

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Literature Corpus work: 39b2d030-e2f7-51d8-99f7-82db59f65f90
DOI: 10.64898/2026.07.06.736185

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