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Ovarian Cancer Patient-Derived Organoids Used as a Model for Replicating Genetic Characteristics and Testing Drug Responsiveness: A Preliminary Study.

Cell transplantation - 1 Jan 2024

Chang Yu-Hsun, Wu Kun-Chi, Wang Kai-Hung, Ding Dah-Ching

Abstract excerpt

This study aimed to explore the role of ovarian cancer patient-derived organoids (PDOs) in their replicating genetic characteristics and testing drug responsiveness. Ovarian cancer PDOs were cultured in Matrigel with a specialized medium. The successful rate and proliferation rate were calculated. Morphology, histology, and immunohistochemistry (IHC) (PAX8, P53, and WT1) were used to identify the tumor...

Topics

Humans
Female
Ovarian Neoplasms
Organoids
Antineoplastic Agents
Middle Aged
Mutation
DNA Copy Number Variations

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39323050
DOI: 10.1177/09636897241281869
PMCID: PMC11425734

Genes

ARID1A
BRCA1
PAX8
PIK3CA
TP53
WT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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