Article

A small molecule enhances arrestin-3 binding to the β <sub>2</sub> -adrenergic receptor

2024-12-13

Abstract excerpt

G protein-coupled receptor (GPCR) signaling is terminated by arrestin binding to a phosphorylated receptor. Binding propensity has been shown to be modulated by stabilizing the pre-activated state of arrestin through point mutations or C-tail truncation. Here, we hypothesize that pre-activated rotated states can be stabilized by small molecules, and this can promote binding to phosphorylation-deficient receptors,...

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Literature Corpus work: f43b7315-69ec-5aaa-841b-a0c0675b6674
DOI: 10.1101/2024.12.12.628161

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