The Functional Role of Gate Loop Residues in Arrestin Binding to GPCRs.

Abstract excerpt

In all arrestins, the gate loop is the central part of the lariat loop, which has an unusual shape and participates in maintaining the basal conformation. The gate loop supplies two out of five charges that constitute a stabilizing intramolecular interaction, aspartates in the polar core between the two domains. To elucidate the functional role of individual gate loop residues, we performed comprehensive...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Arrestin
• Share to Binding Sites
• Share to Models, Molecular