Article
The orientation and stability of the GPCR-Arrestin complex in a lipid bilayer.
Scientific reports - 5 Dec 2017
Wang Dali, Yu Hua, Liu Xiangdong, Liu Jianqiang, Song Chen
Abstract excerpt
G protein-coupled receptors (GPCRs) constitute a large family of membrane proteins that plays a key role in transmembrane signal transduction and draw wide attention since it was discovered. Arrestin is a small family of proteins which can bind to GPCRs, block G protein interactions and redirect signaling to G-protein-independent pathways. The detailed mechanism of how arrestin interacts with GPCR remains...
Topics
- Arrestin
- Hydrogen Bonding
- Lipid Bilayers
- Molecular Dynamics Simulation
- Multiprotein Complexes
- Mutation
- Phosphatidylcholines
- Protein Conformation
- Protein Stability
- Rhodopsin