Article
Conformational Dynamics and Functional Implications of Phosphorylated β-Arrestins.
Structure (London, England : 1993) - 3 Mar 2020
Kang Hyunook, Yang Han-Sol, Ki Ah Young, Ko Seung-Bum, Kim Kwon Woo, Shim Chang Yong, Kim Kiae, Choi Hee-Jung, Chung Ka Young
Abstract excerpt
Arrestins desensitize and/or internalize G-protein-coupled receptors by interacting with phosphorylated receptors. A few studies have reported that arrestins themselves can be phosphorylated, and the phosphorylation status modulates their cellular functions. However, the effects of phosphorylation on arrestin structure have not been studied. Here, we investigated the conformational changes in β-arrestin-1 and -2...
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