Article

Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785

2024-07-25

Abstract excerpt

Voltage-gated K+ channels play central roles in human physiology, both in health and disease. A repertoire of inhibitors that are both potent and specific would therefore be of great value, not only as pharmacological agents but also as research tools. The small molecule RY785 has been described as particularly promising in this regard, as it selectively inhibits channels in the Kv2 subfamily with high potency. Kv...

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Literature Corpus work: f422f848-2334-5e0a-a95f-522fbcd08e35
DOI: 10.1101/2024.07.25.605170

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