Article
Site and Mechanism of ML252 Inhibition of Kv7 Voltage-Gated Potassium Channels.
Function (Oxford, England) - 1 Jan 2023
Kanyo Richard, Lamothe Shawn M, Urrutia Arturo, Goodchild Samuel J, Allison W Ted, Dean Richard, Kurata Harley T
Abstract excerpt
Kv7 (KCNQ) voltage-gated potassium channels are critical regulators of neuronal excitability and are candidate targets for development of antiseizure medications. Drug discovery efforts have identified small molecules that modulate channel function and reveal mechanistic insights into Kv7 channel physiological roles. While Kv7 channel activators have therapeutic benefits, inhibitors are useful for understanding...
Topics
- Animals
- Potassium Channels, Voltage-Gated
- Tryptophan
- Zebrafish
- Mutation