Article

U2AF regulates the translation and localization of nuclear-encoded mitochondrial mRNAs

2024-09-18

Abstract excerpt

<h4>Summary</h4> The mechanisms underlying molecular targeting to mitochondria remain enigmatic, yet this process is crucial for normal cellular function. The RNA binding proteins U2AF1/2 form a heterodimer (U2AF) that shuttles between the nucleus and cytoplasm, regulating splicing in the nucleus and translation in the cytoplasm. Our study identifies an unexpected role for U2AF in mitochondrial function. We demon...

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Literature Corpus work: f421ef10-3c56-5a47-900e-512824dd794f
DOI: 10.1101/2024.09.18.613780

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