Article

The Role of U2AF1 Mutation in Malignant Diseases and Related Therapeutic Strategies

2023-02-09

Abstract excerpt

The U2 small nuclear RNA auxiliary factor1（U2AF1）belongs to the splicing factor SR family. This spliceosome involves in intron removal from messenger RNAs (mRNAs) and exon-exon binding. Nevertheless, the mutation of U2AF1 is associated with myelodysplastic syndrome (MDS), bone marrow cancer, and solid tumors, including lung cancer, pancreatic carcinoma, and other malignant tumors. Besides, the expression and mutat...

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Literature Corpus work: 493f8ee7-c5dc-59f2-bd55-4988cda75766
DOI: 10.22541/au.167597300.09787007/v1

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