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Article

Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation.

PLoS biology - 1 Nov 2020

Akef Abdalla, McGraw Kathy, Cappell Steven D, Larson Daniel R

Abstract excerpt

U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) forms a heterodimeric complex with U2AF2 that is primarily responsible for 3' splice site selection. U2AF1 mutations have been identified in most cancers but are prevalent in Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML), and the most common mutation is a missense substitution of serine-34 to phenylalanine (S34F). The U2AF heterodimer also has a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33137094
DOI: 10.1371/journal.pbio.3000920
PMCID: PMC7660540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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