Article

The splicing factor U2AF1 contributes to cancer progression through a non-canonical role in translation regulation

2018-07-18

Abstract excerpt

Somatic mutations in the genes encoding components of the spliceosome occur frequently in human neoplasms, including myeloid dysplasias and leukemias and less often in solid tumors. One of the affected factors, U2AF1, is involved in splice site selection, and the most common change, S34F, alters a conserved nucleic acid binding domain, recognition of the 3’-splice site, and alternative splicing of many mRNAs. Howe...

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Literature Corpus work: 387aeec8-869a-55e6-9917-b3c79ae02f49
DOI: 10.1101/371492

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