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Article

U2AF1 in various neoplastic diseases and relevant targeted therapies for malignant cancers with complex mutations (Review).

Oncology reports - 1 Jan 2024

Nian Qing, Li Yihui, Li Jingwei, Zhao Liyun, Rodrigues Lima Fernando, Zeng Jinhao, Liu Rongxing, Ye Zhijun

Abstract excerpt

U2 small nuclear RNA auxiliary factor 1 (U2AF1) is a multifunctional protein that plays a crucial role in the regulation of RNA splicing during eukaryotic gene expression. U2AF1 belongs to the SR family of splicing factors and is involved in the removal of introns from mRNAs and exon-exon binding. Mutations in U2AF1 are frequently observed in myelodysplastic syndrome, primary myelofibrosis, chronic myelomonocytic...

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Identifiers

PMID: 37975232
DOI: 10.3892/or.2023.8664
PMCID: PMC10688450

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