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Article

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.

Nature cell biology - 1 Jun 2017

Liu Xin, Zhang Yuannyu, Ni Min, Cao Hui, Signer Robert A J, Li Dan, Li Mushan, Gu Zhimin, Hu Zeping, Dickerson Kathryn E, Weinberg Samuel E, Chandel Navdeep S, DeBerardinis Ralph J, Zhou Feng, Shao Zhen, Xu Jian

Abstract excerpt

Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype. Here we compare the genome-scale proteomic and transcriptomic changes in human primary haematopoietic stem/progenitor cells and erythroid progenitors, and uncover pathways related to mitochondrial biogenesis enhanced through post-transcriptional regulation....

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Identifiers

PMID: 28504707
DOI: 10.1038/ncb3527
PMCID: PMC5771482

Genes

TFAM
PHB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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