Article

Deciphering <i>TP53</i> mutant Cancer Evolution with Single-Cell Multi-Omics

2022-03-29

Abstract excerpt

<h4>Summary</h4> TP53 is the most commonly mutated gene in human cancer, typically occurring in association with complex cytogenetics and dismal outcomes. Understanding the genetic and non-genetic determinants of TP53- mutation driven clonal evolution and subsequent transformation is a crucial step towards the design of rational therapeutic strategies. Here, we carry out allelic resolution single-cell multi-omic...

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Literature Corpus work: f414f662-ad90-5c27-af9a-d3037fcff69c
DOI: 10.1101/2022.03.28.485984

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