Prognostic impact of 'multi-hit' versus 'single-hit' TP53 alteration in patients with acute myeloid leukemia: results from the Consortium on Myeloid Malignancies and Neoplastic Diseases.

doi:10.3324/haematol.2024.285000

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Prognostic impact of 'multi-hit' versus 'single-hit' TP53 alteration in patients with acute myeloid leukemia: results from the Consortium on Myeloid Malignancies and Neoplastic Diseases.

Haematologica - 1 Nov 2024

Badar Talha, Nanaa Ahmad, Atallah Ehab, Shallis Rory M, Craver Emily C, Li Zhuo, Goldberg Aaron D, Saliba Antoine N, Patel Anand, Bewersdorf Jan P, Duvall Adam, Burkart Madelyn, Bradshaw Danielle, Abaza Yasmin, Stahl Maximilian, Palmisiano Neil, Murthy Guru Subramanian Guru, Zeidan Amer M, Kota Vamsi, Patnaik Mrinal M, Litzow Mark R

Abstract excerpt

While there is clear evidence to suggest poorer outcome associated with multi-hit (MH) TP53 mutation (TP53MT) compared to a single-hit (SH) mutation in lower-risk myelodysplastic syndrome (MDS), data are conflicting in both higher-risk MDS and acute myeloid leukemia (AML). We conducted an in-depth analysis utilizing data from ten US academic institutions to study differences in molecular characteristics and...

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Identifiers

PMID: 38813716
DOI: 10.3324/haematol.2024.285000
PMCID: PMC11532685

Genes

IDH1
TP53
ASXL1
FLT3
NPM1

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