Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution.

doi:10.1038/s41588-023-01480-1

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Article

Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution.

Nature genetics - 1 Sept 2023

Rodriguez-Meira Alba, Norfo Ruggiero, Wen Sean, Chédeville Agathe L, Rahman Haseeb, O'Sullivan Jennifer, Wang Guanlin, Louka Eleni, Kretzschmar Warren W, Paterson Aimee, Brierley Charlotte, Martin Jean-Edouard, Demeule Caroline, Bashton Matthew, Sousos Nikolaos, Moralli Daniela, Subha Meem Lamia, Carrelha Joana, Wu Bishan, Hamblin Angela, Guermouche Helene, Pasquier Florence, Marzac Christophe, Girodon François, Vainchenker William, Drummond Mark, Harrison Claire, Chapman J Ross, Plo Isabelle, Jacobsen Sten Eirik W, Psaila Bethan, Thongjuea Supat, Antony-Debré Iléana, Mead Adam J

Abstract excerpt

Understanding the genetic and nongenetic determinants of tumor protein 53 (TP53)-mutation-driven clonal evolution and subsequent transformation is a crucial step toward the design of rational therapeutic strategies. Here we carry out allelic resolution single-cell multi-omic analysis of hematopoietic stem/progenitor cells (HSPCs) from patients with a myeloproliferative neoplasm who transform to TP53-mutant...

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Identifiers

PMID: 37666991
DOI: 10.1038/s41588-023-01480-1
PMCID: PMC10484789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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