Breaking the guardian of the genome: TP53 dysfunction in myeloid neoplasms.

Abstract excerpt

Since its discovery more than 40 years ago, TP53 has emerged as the most iconic gene in cancer biology. Early studies of mutant constructs led researchers to misclassify TP53 as an oncogene, a misconception later resolved when wild-type p53 was shown to function as a tumor suppressor. p53 is now widely recognized as the central guardian of genomic integrity, coordinating DNA-damage responses, cell-cycle control,...

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• DNA Damage
• TP53 gene
• Mutation
• Myelodysplastic Syndromes
• Tumor Suppressor Protein p53