Recent advances in the understanding of TP53 in haematological malignancies.

doi:10.1016/j.pathol.2026.03.014

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Article

Recent advances in the understanding of TP53 in haematological malignancies.

Pathology - 1 Aug 2026

Ng Jun Yen, Talaulikar Dipti

Abstract excerpt

TP53 is the most frequently mutated gene in human cancers, with significant diagnostic, prognostic, and therapeutic implications in haematological malignancies. The TP53 gene encodes the p53 protein, a central regulator of cell cycle arrest, apoptosis, and DNA repair. Loss-of-function TP53 mutations lead to resistance to chemotherapy and poor outcomes across both myeloid and lymphoid neoplasms. Recent advances in...

Topics

Humans
Hematologic Neoplasms
Tumor Suppressor Protein p53
Mutation

Source

Open in PubMed

Identifiers

PMID: 42342465
DOI: 10.1016/j.pathol.2026.03.014

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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