Article

Altered nuclear envelope homeostasis is a key pathogenic event in C9ORF72-linked ALS/FTD

2024-02-04

Abstract excerpt

<h4>SUMMARY</h4> ALS and FTD are complex neurodegenerative disorders that primarily affects motor neurons in the brain and spinal cord, and cortical neurons in the frontal lobe. Although the pathogenesis of ALS/FTD is unclear, recent research spotlights nucleocytoplasmic transport impairment, DNA damage, and nuclear abnormalities as drivers of neuronal death. In this study, we show that loss of nuclear envelope (...

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Literature Corpus work: 85d54cfc-639d-54b2-8947-63b58b88b91b
DOI: 10.1101/2024.02.01.578318

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