Article

Tau modulates nuclear integrity, chromatin, and cholesterol synthesis genes via the nuclear envelope

2025-12-09

Abstract excerpt

<h4>Abstract/Summary</h4> The intracellular re-distribution of the neuronal microtubule-associated protein Tau, from the axon into the somatodendritic compartment, is a physiological stress-related event and occurs early in Alzheimer’s disease (AD). Nuclear envelope distortions have been linked to the presence and aggregation of pathological Tau near the nucleus in these diseases. How physiologically increased so...

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Identifiers and source

Literature Corpus work: cceae1b7-0b72-51a0-a331-86c9945e82e7
DOI: 10.64898/2025.12.05.692577

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