Article

Access to germinal center IL-4 microniches drives tissue-divergence of IgE memory responses

2025-12-05

Abstract excerpt

Immunoglobulin E (IgE) drives allergic disease, yet how memory B cells (MBCs) reactivate to produce IgE, and how tissue localization shapes recall responses, remains unclear. Using mouse models of airborne exposure to house dust mites and Alternaria , we found that allergen sensitization generates lymphoid- and lung-resident MBCs. Upon allergen re-exposure, these populations followed distinct differentiation traj...

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Literature Corpus work: f40c0095-88ac-501a-a340-9e1715d4ef63
DOI: 10.64898/2025.12.03.692086

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