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Article

The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma

2 Jun 2021

Abstract excerpt

Repetitive exposure of Rag1-/- mice to the Alternaria allergen extract generated a form of memory that elicited an asthma-like response upon a subthreshold recall challenge 3-15 wk later. This memory was associated with lung ICOS+ST2+ ILC2s. Genetic, pharmacologic, and antibody-mediated inhibition and adoptive transfer established an essential role for ILC2s in memory-driven asthma. ATAC-seq demonstrated a...

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PMID: 34076685
DOI: 10.1084/jem.20201354

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