Article

Interrupting reactivation of immunological memory reprograms allergy and averts anaphylaxis

2020-03-05

Abstract excerpt

IgE production against innocuous antigens can lead to life-threatening reactions such as anaphylaxis. While IgE levels drastically decline with strict allergen avoidance, the ability to regenerate IgE can persist for a lifetime, as is the case for peanut allergy. The mechanism by which IgE regenerates remains unresolved. A novel culture system and application of single-cell RNA-sequencing, elucidated the transcrip...

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Literature Corpus work: e13814e1-e918-56d9-bb68-0217a74922f4
DOI: 10.1101/2020.03.04.975706

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