Article

Pathogenic IgE-fated memory B cell responses retain functional plasticity

2023-11-29

Abstract excerpt

Long-lived immunoglobulin (Ig) E responses against innocuous environmental and dietary antigens (Ags) are maintained by an IgG1-dominant memory B cell (MBC) compartment primed for IL-4 responsiveness. The plasticity of the MBC compartment destined for IgE class switch recombination (CSR), however, remains poorly understood. In this work, we report a critical IL-4/IL-13 dependency for the pathogenic IgE fate of typ...

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Literature Corpus work: a8a09acb-c711-541a-80d6-fc903fab027c
DOI: 10.1101/2023.11.28.567094

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