Article

A Distinct Phenotype of Polarized Memory B cell holds IgE Memory

2023-01-25

Abstract excerpt

Allergen-specific IgE antibodies mediate allergic pathology in diseases such as allergic rhinitis and food allergy. Memory B cells (MBCs) contribute to circulating IgE by regenerating IgE-producing plasma cells upon allergen encounter. We report a population of type 2 polarized MBCs defined as CD23 hi , IL-4Rα hi , CD32 low at the transcriptional and surface protein levels. These “MBC2s” are enriched in IgG1 an...

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Literature Corpus work: c2585429-a252-56ac-989b-52f54662f37f
DOI: 10.1101/2023.01.25.525495

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