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Article

Targeting the ICOS / ICOS ‐L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease

16 Sept 2018

Abstract excerpt

Abstract Background Allergic asthma is characterized by chronic inflammation and remodelling of the airways, associated with dysregulated type 2 immune responses and allergen‐specific IgE. T follicular helper cells ( T FH ) are crucial in T‐dependent B‐cell responses and have been implicated in allergic airway disease ( AAD ). T FH , unlike other CD 4 + T cells, are uniquely reliant on continuous ICOS signalling...

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PMID: 30220084
DOI: 10.1111/all.13602

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