Article

Choroid plexus APP regulates adult brain proliferation and animal behavior

2019-08-26

Abstract excerpt

Elevated amyloid precursor protein (APP) expression in the choroid plexus suggests an important role for extracellular APP metabolites in cerebrospinal fluid. Despite widespread App brain expression, we hypothesized that specifically targeting choroid plexus expression could alter animal physiology. Through various genetic and viral approaches in the adult mouse, we show that choroid plexus APP levels significant...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f404fcac-d0a7-5ca2-be50-55293e116329
DOI: 10.1101/734103

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Choroid plexus APP regulates adult brain proliferation and animal behaviorDOI 10.1101/734103Read

Ptpn20 maintains choroid plexus epithelial integrity to preserve amyloid-β homeostasis in Alzheimer's diseaseSemantic proximity Read

Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer’s diseaseSemantic proximity Read

Multi-modal choroid plexus pathology in aging and Alzheimer’s diseaseSemantic proximity Read

Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice.Semantic proximity Read

Wild-Type Neural Progenitors Divide and Differentiate Normally in an Amyloid-Rich EnvironmentSemantic proximity Read

Alterations in choroid plexus gene expression in Alzheimer’s disease provide inferences for CSF composition and dynamicsSemantic proximity Read

Amyloid plaque deposition accelerates tau propagation via activation of microglia in a humanized APP mouse modelSemantic proximity Read

Ngfr suppresses Lcn2/Slc22a17 signaling, induces neurogenesis and reduces amyloid pathology in the hippocampus of APP/PS1dE9 mouseSemantic proximity Read

Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to beta-amyloid.Semantic proximity Read

Extracranial lymphatic–venous anastomosis remodels the choroid plexus–vascular axis in Alzheimer’s diseaseSemantic proximity Read

Modeling the prodromal phase of Alzheimer’s disease: Selective amyloid-driven failure of cholinergic medial septal neurons perturbs REM sleep, cognition, emotion, and broadcasts pathology in aging miceSemantic proximity Read

CD38 Inhibition Ameliorates Age-Related Cognitive Decline via a Choroid Plexus–Cerebrospinal Fluid–Hippocampus AxisSemantic proximity Read