CD38 Inhibition Ameliorates Age-Related Cognitive Decline via a Choroid Plexus–Cerebrospinal Fluid–Hippocampus Axis

Abstract excerpt

<title>Abstract</title> <p>Age-related cognitive decline represents a major and unresolved challenge of human aging. Here, we identify the NAD⁺-consuming enzyme CD38 as a central regulator of cognitive aging acting through a choroid plexus–cerebrospinal fluid (CSF)–hippocampus axis. CD38 expression increases with age and localizes primarily to pericytes in the choroid plexus, where it depletes NAD⁺, impairs mitoc...

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Identifiers and source

Literature Corpus work

185d55db-2f92-5a74-a3f5-2941b7b2220d

DOI

10.21203/rs.3.rs-8330519/v1