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Article

Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to beta-amyloid.

Neurobiology of aging - 1 Apr 2006

Calafiore M, Battaglia G, Zappalà A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino M A, Nicoletti F, Copani A

Abstract excerpt

Neurospheres from adult mouse subventricular zone (SVZ) were grown in suspension cultures for 12-15 days. Neurospheres consisted mainly of neural precursor cells (NPCs) immunoreactive for nestin and also contained nestin-negative precursors. We used these neurospheres to determine the effects of synthetic beta-amyloid fragments (both betaAP(1-42) and betaAP(25-35)) on NPC proliferation, differentiation and...

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PMID: 15964102
DOI: 10.1016/j.neurobiolaging.2005.03.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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