Article

Stiffness Regulates Intestinal Stem Cell Fate

2021-03-16

Abstract excerpt

<h4>Summary</h4> Does fibrotic gut stiffening caused by inflammatory bowel diseases (IBD) direct the fate of intestinal stem cells (ISCs)? To address this question we first developed a novel long-term culture of quasi-3D gut organoids plated on hydrogel matrix of varying stiffness. Stiffening from 0.6kPa to 9.6kPa significantly reduces Lgr5 high ISCs and Ki67 + progenitor cells while promoting their differentia...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f3dbbcd3-1251-5edd-ab68-3b3bb16e4fbc
DOI: 10.1101/2021.03.15.435410

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stiffness Regulates Intestinal Stem Cell FateDOI 10.1101/2021.03.15.435410Read

Stiffness Regulates Intestinal Stem Cell FateSemantic proximity Read

A Centimeter-Scale, Peristaltic Human Intestinal Organoid with Integrated Neuro-Immune-Vascular Systems Recapitulates Enteritis and Orthotopic Colorectal CancerSemantic proximity Read

Extracellular Matrix Mechanical Properties and Regulation of the Intestinal Stem Cells: When Mechanics Control Fate.Semantic proximity Read

Mechanical stretching boosts expansion and regeneration of intestinal organoids through fueling stem cell self-renewalSemantic proximity Read

Intestinal Stem and Progenitor Cells Exhibit Distinct Adaptive Responses to Inflammatory Stress in IBDSemantic proximity Read

Centimeter-scale, physiologically relevant intestinal organoids generated entirely from pluripotent stem cellsSemantic proximity Read

Intestinal Stem Cell-on-Chip to Study Human Host-Microbiota InteractionSemantic proximity Read

Interleukin-11 promotes colonic epithelial repair after mechanical disruptionSemantic proximity Read

An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cellsSemantic proximity Read

Intestinal organoids in inflammatory bowel disease: advances, applications, and future directionsSemantic proximity Read

Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular ComponentsSemantic proximity Read

Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammationSemantic proximity Read