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Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation

28 Nov 2022

Abstract excerpt

BACKGROUND: The emerging concepts of fetal-like reprogramming following tissue injury have been well recognized as an important cue for resolving regenerative mechanisms of intestinal epithelium during inflammation. We previously revealed that the remodeling of mesenchyme with collagen fibril induces YAP/TAZ-dependent fate conversion of intestinal/colonic epithelial cells covering the wound bed towards fetal-like...

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PMID: 36443773
DOI: 10.1186/s41232-022-00237-3

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